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pet care

Avance

The Effects of The ONSEN INGREDIENT, ONSEN ALGAE RG92

Located in Beppu city, where 10 of the 11 hot-spring types that have been found to be medically effective, and it has the world's largest number of hot spring sources (about 3,000) in the world.

After we have spent many daunting weeks investigating different forms of algae from innumerable microorganisms living in these sources. From these efforts and an astounding amount of verification, we discovered several new species of algae (confirmed through genetic analysis at the Shinshu University in the Nagano Prefecture.

Among the new species, the algae type having the highest levels of anti-inflammatory action was named "RG92"® (a new Regeneration Gateway discovered during the 92nd analysis of hot spring algae for healing).

Ingredients:

Water, Hydrolysed Yeast Extract, Hydrolyzed Collagen,RG92® Algae Extract,
Eucalyptus Leaf Extract, Rosemary Leaf Extract.

Additive-free
Alcohol-free
Preservative-free

RG92® Algae Extract Patent No. #5676702 (January 9, 2015)
RG92® Algae Extract ECOCERT Certified.
Hydrolyzed Yeast Extract ECOCERT Certified.

It was later revealed that the discovered hot-spring ingredient, RG92®, excels with a highly anti-inflammatory effect which alleviates the damage caused by "oxidation" and "glycation".

With the discovery of the new species of spa algae, its anti-inflammatory effects, and its development as a therapeutic agent for health have been recognized and awarded patent in 2015.
In addition, we validated not only relief of pain (lower back pain, joint pain, rheumatism) but also atopic dermatitis, acne and itching improvement, and consecutively presented research on this subject at several medical scientific conferences.

On the 25th of March, 2015, we held an academic presentation at the 135th Annual Meeting of the Pharmaceutical Society of Japan (Kobe, Japan). On this occasion, we presented our results of our research that verified that the hot spring ingredient, RG92®, promoted healing and regenerative functions such as anti-inflammatory functions and the restoring of injured tissues.
For the investigation, the hot-spring ingredient, RG92®, was applied to a disease model of Arthritis, Dermatitis and a Glycation-induced alopecia type.

The results concluded that the production of inflammatory factors such as TNF-α, IL-1β and extracellular matrix degrading enzymes were inhibited with the application of RG92®.
Furthermore, the hot-spring ingredient, RG92® was found to have effects of protecting cells from stress agents such as glycation and oxidation.
In addition to this, we also confirmed that RG92® induced the increase in Cartilage Collagen, the moisture regulatory factor AQP11 and the longevity gene SIRT1 in fibroblasts.

What are fibroblasts?

A fibroblast is a type of cell that is responsible for making the extracellular matrix and collagen. Together, this extracellular matrix and collagen form the structural framework of tissues in animals and plays an important role in tissue repair. Fibroblasts are the main connective tissue cells present in the body.

SKIN TROUBLE

  • Skin Inflammation
  • Sunburn
  • Acne
  • Atopic Dermatitis
  • Itchiness

Caused by, Increase in inflammatory factors, pain factors and cell damage, Decrease in moisturizing power, increase in lgE antibodies.

MUSCLE & JOINT TROUBLE

  • Arthralgia (Joint Pain)
  • LOwer back pain
  • Muscle pain

Caused by increase of inflammatory factors and pain factors in joint cells, increase of extracellular matrix degrading enzyme, Overproduction of synovial fluid.

The hot-spring ingredient, RG92®, was found to act as a regulator in the above mechanisms (data below).
Suppression of arthritic pain, inflammation and cartilage degradation.
RG92 extract suppresses factors involved in joint pain and inflammation and enhances joint function.

AVANCE is recommended for:

COMPANION ANIMALS
HORSES
SWINE
POULTRY 
RUMINANTS

Effects of Avance use, Illustration of BEFORE and AFTER

  • Name : Oinari
  • Gender : Male
  • Age : 6
  • Breed : French Bulldog   
Before
After
  • Name : Momo
  • Gender : Male
  • Age : 11
  • Breed : Chihuahua
Before
After
  • Name : Ponz
  • Gender : Male
  • Age : 9
  • Breed : Miniature Dachshund
Before
After
  • Name : Lum
  • Gender : Female
  • Age : 11
  • Breed : Miniature Dachshund
Before
After

Animal species : Angola Ferret

Before
After

Animal species : Rabbit

Before
After

Small size dog - Paw

Before
After

How to use Avance

1

Divide the hair to reveal the skin to spray

2

Hold around the tummy to spray easier

3

Use cotton to absolve the lotion to apply around tear burns to clean

4

Use cotton to absolve the lotion to apply to wide part of the ear

5

For detail area of the ear use ear cotton to absolve the lotion

6

To clean and clear the dirt from the ear use the ear cotton

7

To treat the paws use

8

Spray directly to care

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