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7th World Congress for Hair Research : Presentation & Best Research Presentation Award 2013

7th World Congress for Hair Research : Presentation & Best Research Presentation Award 2013

Background

The most prestigious congress in the hair industry segment. It is also the world's largest academic conference attended by some of the world's highest ranked scientists and specialists from prestigious universities around the world who attend to evaluate the latest hair research studies. It was at this event that for the first time in the history of this event that a Saravio Cosmetics Ltd., a private Japanese company, won the "Best Presentation Award" out of 250 for its presentation on "New hair growth activation mechanism (microsensor theory)".

Other Award Recipients

・ Columbia University School of Medicine Dermatology (USA)
・ Saravio Cosmetics Ltd. (Saravio Central Institute) (Japan)
・ University of Sheffield Medical Nursing Faculty of infectious diseases and Immunology Department (UK)
・ University of Bradford skin Science Center (UK)
・ University of British Columbia Dermatology (Canada)
・ Mount Sinai School of Medicine regenerative medicine (USA)

Presentation Contents

Dermal papilla cells are said to be the controllers of hair growth signals, which are predominantly a main research topic among hair care researchers. The hair cycle (Anagen-Catagen-Telogen) is controlled by signal transmissions between the hair follicle cells (exchange between cell growth factor etc).

It is also considered that cilium is deeply involved in the transmission of hair growth signal of dermal papilla cells. Researchers at the Saravio Central Research Institute have been focusing on elucidating the molecular mechanism of dermal papilla cells which control hair growth and have discovered that the primary cilia of dermal papilla cells are involved in the inhabitation for generation of hair matrix cells (cells that form hair) and fibroblasts (the hair root).

Analysis regarding the proliferation factor affecting this inhabitation and the relation to mitochondrial activity are also currently underway at the Central Research Institute.

Primary cilia-mediated cellular signalling in dermal papilla cells

Abstract

Dermal papilla cells (DPCs) produce various intercellular signalling molecules and thereby play essential roles in hair growth and development. Great amount of attention has been paid to an antenna-like organelle (primary cilium) as a signalling centre in mammalian cells. However, little is known about the roles of primary cilia in DPC. Here we show that the DPC cilium is involved in producing cell growth factors.

Immunochemistry, together with electron microscopic observations, showed that primary cilia protrude from cultured human follicular DPC (Fig. 1). The ciliary length was distributed around 2 mm and the diameter was approximately 0.2 mm, which is similar to previous observations in other mammalian cells.

In order to investigate the role of the organelle in intercellular signalling, mesenchymal stromal (mouse 3T3-L1) cells were grown in DPC-conditioned media and the cellular viability was analysed (Fig. 2). In the presence of lithium chloride, the ciliary length of DPC became longer and the mesenchymal stromal cells became more viable. A similar result was obtained with keratinocytes. In contrast, shortening of DPC cilia by KIF3A knockdown reduced the viability of the mesenchymal cells. These results suggest that cilium-based signalling in DPC plays a key role in maintaining other cells.

In search of regulators of DPC cilia, we have found that basic fibroblast growth factor (bFGF) and hydrolysed yeast extract elongated the cilia significantly (Fig. 3 and 4). Interestingly, the latter increased filamentous mitochondria, augmented mitochondrial activity and increased expression level of FGF-10 in DPC.

WCHR 2013 Research details

 

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